Coming off two straight losses, including a blowout at home against the Washington Commanders, the Arizona Cardinals are in for a long afternoon against the San Francisco 49ers.
Even without Christian McCaffrey, the 49ers have shown flashes that they’ll again be a Super Bowl contender. I expect the run game to be the difference in my Cardinals vs. 49ers predictions and NFL picks for Sunday, October 6.
Cardinals vs 49ers prediction
My best betJordan Mason 100+ rushing yards (+130 at BetMGM)
My analysis
Losing a player like Christian McCaffrey can derail most teams’ seasons, but the Shanahan family has a history of turning nobody running backs into stars. Mike and Kyle Shanahan know how to get the best out of any …